Lewis joined the faculty of the School of Engineering and Applied Sciences and the Wyss Institute for Biologically Inspired Engineering at Harvard University in 2013. Prior to her appointment at Harvard, she served as the director of the Frederick Seitz Materials Research Laboratory and the Hans Thurnauer Professor of Materials Science and Engineering at the University of Illinois at Urbana-Champaign. Her work has resulted in eight patents and 125 papers to date. Her research on microscale 3D printing was recently highlighted as one of the "10 Breakthrough Technologies" by the MIT Technology Review. Lewis is the recipient of the National Science Foundation (NSF) Presidential Faculty Fellow Award, the Brunaeur Award from the American Ceramic Society, the Langmuir Lecture Award from the American Chemical Society, and the Materials Research Society (MRS) Medal. She is a Fellow of the American Ceramic Society, the American Physical Society, the Materials Research Society, and the American Academy of Arts and Sciences. She serves on the editorial advisory boards of Advanced Materials, Advanced Functional Materials and Soft Matter.